|Martin Gibala, PhD|
Professor and Chair
Location: Ivor Wynne Centre, Room 210
My research examines the regulation of skeletal muscle energy provision. I am particularly interested in the potential for exercise and/or nutrition to induce metabolic adaptations at the molecular and cellular levels in humans. In addition to basic, mechanistic studies, I also conduct applied research that examines the impact of exercise training and dietary manipulation on sport performance. Recent work in my laboratory has focused on two main areas:
(1) Metabolic adaptations to low-volume, high-intensity interval training, with an emphasis on the regulation of oxidative energy provision.
(2) The potential for alterations in nutrient availability to impact the acute or chronic adaptations to exercise training.
(names of students supervised are *)
Little JP*, Safdar A, Bishop D, Tarnopolsky MA, Gibala MJ. An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1? and activates mitochondrial biogenesis in human skeletal muscle. Am J Physiol Reg Integr Comp. (R-00538-2010). In press; accepted Mar 2011.
Hood MS*, Little JP*, Tarnopolsky MA, Myslik F*, Gibala MJ. Low-volume interval training improves muscle oxidative capacity in sedentary adults. Med Sci Sports Exerc (MSSE-D-10-00721). In press; accepted Mar 2011.
Howarth KR*, Phillips SM, MacDonald MM, Richards DL, Moreau NM*, Gibala MJ. Effect of glycogen availability on human skeletal muscle protein turnover during exercise and recovery. J Appl Physiol 109: 431-438, 2010.
Cochran AJC*, Little JP*, Tarnopolsky MA, Gibala MJ. Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans. J Appl Physiol. 108:628-636, 2010.
Little JP*, Safdar AS, Wilkin GP*, Tarnopolsky MA, Gibala MJ. A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms. J Physiol. 586: 1011-1022, 2010.
Cermak NM*, Solheim A*, Gardner MS*, Tarnopolsky M, Gibala MJ. Muscle metabolism during exercise with protein or protein-carbohydrate ingestion. Med Sci Sports Exerc. 41:2158-2164, 2009.
Howarth KR*, Moreau N, Phillips SM*, Gibala MJ. Co-ingestion of protein with carbohydrate during recovery from endurance exercise stimulates skeletal muscle protein synthesis in humans. J Appl Physiol. 106:1394-1402, 2009.
Gibala MJ, McGee SL, Garnham A, Howlett K, Snow R, Hargreaves M. Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1? in human skeletal muscle. J Appl Physiol. 106:929-934, 2009.
Gibala MJ, Rakobowchuk M. Physiological adaptations to training. In: The Olympic Textbook of Science in Sport, edited by Maughan R. West Sussex, UK: Wiley-Blackwell, 2008, p. 56-69. (Review).
Gibala MJ, McGee S. Metabolic adaptations to short-term high-intensity interval training: A little pain for a lot of gain? Exerc Sports Sci Rev. 36:58-63, 2008. (Review).
Burgomaster KA*, Howarth KR*, Rakobowchuk M, Phillips SM, MacDonald MJ, McGee S, Gibala MJ. Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol. 586:151-160, 2008.