Ronald J. Racine
Department of Psychology,
Neuroscience & Behaviour
1280 Main Street West
Hamilton, ON L8S 4K1 -
of Learning and Memory
am interested in how the brain stores information. My students
and I have used model phenomena such as long-term potentiation
(LTP) and kindling to study the mechanisms by which synaptic connections
are altered by patterned activation. The use of these phenomena
allow us to produce controlled changes in synaptic connectivity
at known sites. We can then use electrophysiology, anatomy or molecular
biology techniques to investigate the mechanisms underlying these
addition, I am interested in the rules that apply at the network
level. What conditions must exist in order for synaptic connectivity
to be enhanced? This question leads us to the investigation
of the role of discharge pattern, modulatory systems (inhibitory
as well as excitatory), and temporal contiguity in memory trace
interests include neural network modelling, auditory perception
A.C.W., Ivanco, T.L., LeBoutillier, J.C., Racine, R.J. and
Petit, T.L. Sequential changes in the synaptic structural
profile following long-term potentiation in the rat dentate
gyrus: III. Long-term maintenance phase. Synapse, 2000 (in
C. and Racine, R.J. GABAergic modulation of
neocortical long-term potentiation in the freely moving
rat. Synapse, 2000, 35, 120-128.
T.L., Racine, R.J., and Kolb, B. Morphology
of layer III pyramidal neurons is altered following
induction of LTP in sensorimotor cortex of the freely
moving rat. Synapse, 2000, 37, 16-22.
T.L. and Racine, R.J. Long-term potentiation
in the pathways between the hippocampus and neocortex
in the chronically implanted, freely moving, rat.
Hippocampus, 2000, 10, 143-152.
D., Chapman, A., Trepel, C. and Racine, R.J. Long-term
depression and depotentiation in the neocortex
of the chronic preparation. J. Neuroscience, 2000 20,
C. and Racine, R.J. Blockade
and disruption of neocortical long-term potentiation
following electroconvulsive shock in the adult,
freely moving rat. Cerebral Cortex, 1999, 9,
R.J., Steingart, M. and McIntyre, D.C.
Development of kindling-prone and kindling-resistant
rats: selective breeding and electrophysiological
studies. Epilepsy Research, 1999, 35, 183-195.
C. and Racine, R.J. Long-term potentiation
in the neocortex of the adult, freely moving
rat. Cerebral Cortex, 1998, 8, 719-729.
C.A., Trepel, C., Ivanco, T.L., Froc, D.J., Wilson, K. and Racine, R.J. Changes
in field potentials and membrane currents in rat sensorimotor
cortex following repeated tetanization of the corpus callosum
in vivo. Cerebral Cortex, 1998, 8, 730-742.
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