Faculty

Assistant Professor, Canada Research Chair (Tier II) in Neuromuscular Plasticity in Health and Disease

 Vlad3

Location: Ivor Wynne Centre, Room E207

Phone: 905 525 9140 ext. 24517
E-mail: ljubicic@mcmaster.ca 
Website: Exercise Metaobolism Research Group

Research

Research

Neuromuscular plasticity refers to the remodeling of the neuromuscular system in response to genetic or environmental cues. Neuromuscular disorders, including the neuromuscular alterations that are hallmarks of advanced aging, are more common in Canada then generally appreciated. The central experimental questions that form the foundation of our research program are: 1) What roles do phenotype-modifying proteins play in the maintenance and remodeling of the peripheral neuromuscular system, and 2) Are these molecules efficacious therapeutic targets for neuromuscular disorders? To address these questions, we design investigations around rational lifestyle- and pharmacological-based strategies focused on the manipulation of powerful phenotype-bending molecules in the neuromuscular system. Furthermore, we employ an integrative and rigorous cell-to-animal experimental approach, as well as an innovative combination of molecular physiological solutions. The long-term goal of our research is to expand fundamental understanding of the mechanisms governing neuromuscular plasticity, as well as to identify novel, evidence-based therapeutic strategies to improve the lives of those with compromised neuromuscular systems.


 

Publications

Publications

* indicates students under my supervision, ^ indicates students under my co-supervision.

Péladeau C, ^Ahmed A, Amirouche A, Crawford TE, Bronicki LM, Ljubicic V, Renaud JM, Jasmin BJ. Combinatorial Therapeutic Activation with Heparin and AICAR Stimulates Additive Effects on Utrophin A Expression in Dystrophic Muscles. Hum Mol Genet. 25:24-43, 2016. IF: 6.39.

Ljubicic V, Jasmin BJ. Metformin increases peroxisome proliferator-activated receptor γ co-activator-1α and utrophin A expression in dystrophic skeletal muscle. Muscle Nerve. 52:139-42, 2015.

^Al-Rewashdy H, Ljubicic V, Lin W, Renaud JM, Jasmin BJ. Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation. Hum Mol Genet. 24:1243-55, 2015.

Ljubicic V, ^Burt M, Lunde JA, Jasmin BJ. Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis. Am J Physiol Cell Physiol. 307:C66-C82, 2014.

Zhang Y, Uguccioni G, Ljubicic V, Irrcher I, Iqbal S, Singh K, Ding S, Hood DA. Multiple signaling pathways regulate contractile activity-mediated PGC-1α gene expression and activity in skeletal muscle cells. Physiol Rep. 2:e12008, 2014.

Ljubicic V, ^Burt M, Jasmin BJ. The therapeutic potential of skeletal muscle plasticity in Duchenne muscular dystrophy: phenotypic modifiers as pharmacological targets. FASEB J. 28:548-68, 2014.

Ljubicic V, Jasmin BJ. AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy. Trends Mol Med. 19:614-24, 2013.

Ljubicic V, Khogali S, Renaud JM, Jasmin BJ. Chronic AICAR administration attenuates adaptive signaling in dystrophic skeletal muscle. Am J Physiol Cell Physiol. 302:C110-121, 2012.

Ljubicic V, Miura P, ^Burt M, Boudreault L, Khogali S, Lunde JA, Renaud JM, Jasmin BJ. Chronic AMPK activation evokes the slow, oxidative myogenic program in mdx mouse skeletal muscle. Hum Mol Genet. 20:3478-93, 2011.

Lai RY, Ljubicic V, D’souza DD, Hood DA. Effect of chronic contractile activity on mRNA stability in skeletal muscle. Am J Physiol Cell Physiol. 299:C155-63, 2010.

Joseph AM, Ljubicic V, Adhihetty PJ, Hood DA. Biogenesis of the mitochondrial Tom40 channel in skeletal muscle from aged animals and its adaptability to chronic contractile activity. Am J Physiol Cell Physiol. 298:C1308-14, 2010.

Huang JH, Joseph AM, Ljubicic V, Iqbal S, Hood DA. Effect of age on the processing and import of matrix-destined mitochondrial proteins in skeletal muscle. J Gerontol A Biol Sci. 65:138-46, 2010.

Ljubicic V, Menzies KJ, Hood DA. Mitochondrial dysfunction is associated with a proapoptotic cellular environment in senescent cardiac muscle. Mech Age Dev. 131:79-88, 2010.

Ljubicic V, Joseph AM, Adhihetty PJ, Huang JH, Saleem A, Uguccioni G, Hood DA. Molecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle. AGING 1:818-30, 2009.

Ljubicic V, Joseph AM, Saleem A, Uguccioni G, Collu-Marchese M, Lai RY, Nguyen LM, Hood DA. Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging. Biochim Biophys Acta. 1800:223-234, 2010.

Ljubicic V, Hood DA. Specific attenuation of protein kinase activation in muscle with a high mitochondrial content. Am J Physiol Endocrinol Metab. 297:E749-58, 2009.

Ljubicic V, Hood DA. Diminished contraction-induced intracellular signaling towards mitochondrial biogenesis in aged skeletal muscle. Aging Cell 8:394-404, 2009.

Irrcher I, Ljubicic V, Hood DA. Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells. Am J Physiol Cell Physiol. 296:C116-23, 2009.

Irrcher I, Ljubicic V, Kirwan AF, Hood DA. AMP-activated protein kinase-regulated activation of the PGC-1α promoter in skeletal muscle cells. PLoS ONE 3:e3614, 2008.

Ljubicic V, Hood DA. Kinase-specific responsiveness to incremental contractile activity in skeletal muscle with low and high mitochondrial content. Am J Physiol Endocrinol Metab. 295:E195-E204, 2008.

Chabi B, Ljubicic V, Menzies KJ, Huang JH, Saleem A, Hood DA. Mitochondrial function and apoptotic susceptibility in aging skeletal muscle. Aging Cell 7:2-12, 2008. 

Yoshida Y, Holloway GP, Ljubicic V, Hatta H, Spriet LL, Hood DA, Bonen A. Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle. J Physiol. 582:1317-35, 2007.

Adhihetty PJ, Ljubicic V, Hood DA. Effect of chronic contractile activity on SS and IMF mitochondrial apoptotic susceptibility in skeletal muscle. Am J Physiol Endocrinol Metab. 292:E748-55, 2007.

Hood DA, Irrcher I, Ljubicic V, Joseph AM. Coordination of metabolic plasticity in skeletal muscle. J Exp Biol. 209:2265-75, 2006.

Chabi B, Adhihetty PJ, Ljubicic V, Hood DA. How is mitochondrial biogenesis affected in mitochondrial disease? Med Sci Sport Exerc. 37:2102-10, 2005.

Ljubicic V, Adhihetty PJ, Hood DA. Application of animal models: Chronic electrical stimulation-induced contractile activity. Can J Appl Physiol. 30:625-43, 2005.

Adhihetty PJ, Ljubicic V, Menzies KJ, Hood DA. Differential susceptibility of subsarcolemmal and intermyofibrillar mitochondria to apoptotic stimuli. Am J Physiol Cell Physiol. 289:C994-C1001, 2005.

Ljubicic V, Adhihetty PJ, Hood DA. Role of UCP3 in state 4 respiration during contractile activity–induced mitochondrial biogenesis. J Appl Physiol. 97:976-83, 2004.

Irrcher I, Adhihetty PJ, Joseph AM, Ljubicic V, Hood DA. Regulation of mitochondrial biogenesis in muscle by endurance exercise. Sports Med. 33:783-93, 2003.

Adhihetty PJ, Irrcher I, Joseph AM, Ljubicic V, Hood DA. Plasticity of skeletal muscle mitochondria in response to contractile activity. Exp Physiol. 88:99-107, 2003.

 

Grad Students

Grad Students

Degree Name    
PhD Derek Stouth    
MSc  Athan Dial    
   Alexander Manta  
   Sean Ng  
   Nicole Shen  
   Tiffany van Lieshout  

 

Education

Education

 

Degree University Year
BA York University 2001
MSc York University 2004
PhD York University 2009
PDF University of Ottawa 2014

 

Teaching

Teaching


Undergraduate

Kinesiol 3Z03 -  Neuromuscular Plasticity in Health and Disease

Graduate

KIN 725 - Neuromuscular Biology

 

Contact Kinesiology

The Department of Kinesiology is located in the Ivor Wynne Centre (IWC) and IWC East Building, on the northeast side of the university's central campus.
Department of Kinesiology
McMaster University
1280 Main Street West
Ivor Wynne Centre
Hamilton, ON L8S 4K1
Canada