PhD Student, Radiation Biology
Office: Tandem Accelerator Building 104/A
Phone: (905) 525-9140 ext. 21607
My research is focused upon investigating an alternative mechanism of radiation-induced bystander effect (RIBE) mediation. We are working to investigate intercellular communication via electromagnetic signalling to determine the role of non-targeted radiation effects upon biological systems. The study of non-targeted radiation effects is an important consideration when assessing the consequences of delivering a radiation treatment to a targeted volume of tissue. Non-targeted/bystander literature supports the idea that biological damage is not confined to the directly-irradiated cell population. Thus, there is a need to elucidate the overall significance of bystander effects and furthermore, characterise the mechanisms by which cells communicate to gain a thorough understanding of how bystander effects are disseminated throughout a cultured cell population, a tissue system and ultimately, an organism.
- I am interested in investigating the effects of ionizing radiation upon biological systems both in vivo and in vitro. I am particularly interested in the effects of low-dose radiation exposure and the implications that they have upon radiation workers and patients receiving diagnostic levels of radiation.
Le MT, Mothersill CE, Seymour CB, McNeill FE. Is the false-positive rate in mammography in North America too high? Br J Radiol 2016; 89: 20160045. doi: 10.1259/bjr.20160045
Le M, McNeill FE, Seymour C, Rainbow AJ, Mothersill CE. An observed effect of ultraviolet radiation emitted from beta-irradiated HaCaT cells upon non-beta-irradiated bystander cells. Radiat Res 2015; 183(3): 279-90. doi: 10.1667/RR13827.1
Le M, Mothersill CE, Seymour CB, Ahmad SB, Armstrong A, Rainbow AJ, McNeill FE. Factors affecting ultraviolet-A photon emission from beta-irradiated human keratinocyte cells. Physics Med Biol; 60(2015) 6371-6389.
Poster presentation: Exosome release follows exposure of cells to radiation-induced biophotons to produce a bystander response. 62nd Annual Radiation Research Society Meeting, Big Island HI (2016).
Poster presentation: Investigating the contribution of L-Tryptophan to the UV fluorescence observed from beta-irradiated cells. 15th Annual International Dose-Response Conference. University of Massachussetts Amherst, Amherst MA (2016).
Poster presentation: Radiation-stimulated ultraviolet signal generation and response by various cell lines. 14th Annual International Dose-Response Conference. University of Massachussetts Amherst, Amherst MA (2015).
Oral presentation: Ultraviolet-A photoemission from beta-irradiated HaCaT cells; a possible mechanism for DNA damage induction in bystander cells? 13th International Workshop on Damage to DNA. Massachusetts Institute of Technology, Cambridge MA (2014).
Poster presentation: Ultraviolet-A photoemission from cells upon beta-irradiation and consequent bystander effects. 13th Annual International Dose-Response Conference. University of Massachussetts Amherst, Amherst MA (2014).
Poster presentation:Secondary emission of ultraviolet radiation from human keratinocyte cells subsequent to beta irradiation as a radiation-induced bystander stress mechanism. 59th Annual Radiation Research Society Meeting, New Orleans LA (2013).
Poster presentation: Emission of ultraviolet radiation from human keratinocytes is a potential bystander stress mechanism. 12th Annual International Dose-Response Conference. University of Massachussetts Amherst, Amherst MA (2013).
Biology 1A03: Cellular and Molecular Biology
Biology 2B03: Cell Biology
Med Rad Sci 3Y03: Biomedical Ethics from Medical Radiation Sciences
Med Rad Sci 3X03: Research Methods in Medical Radiation Sciences
MedPhys 4U03: Radiation Biology