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Faculty of Science Radiation Sciences Graduate Program (RadGrad)
Faculty of Science

Radiation Sciences Graduate Program (RadGrad)

Michelle Le

 

  • My research is focused upon investigating an alternative mechanism of radiation-induced bystander effect (RIBE) mediation. We are working to investigate intercellular communication via electromagnetic signalling to determine the role of non-targeted radiation effects upon biological systems. The study of non-targeted radiation effects is an important consideration when assessing the consequences of delivering a radiation treatment to a targeted volume of tissue. Non-targeted/bystander literature supports the idea that biological damage is not confined to the directly-irradiated cell population. Thus, there is a need to elucidate the overall significance of bystander effects and furthermore, characterise the mechanisms by which cells communicate to gain a thorough understanding of how bystander effects are disseminated throughout a cultured cell population, a tissue system and ultimately, an organism.

  • I am interested in investigating the effects of ionizing radiation upon biological systems both in vivo and in vitro. I am particularly interested in the effects of low-dose radiation exposure and the implications that they have upon radiation workers and patients receiving diagnostic levels of radiation.
  • Michelle Le's Thesis

    Publications:

    Le MT, Mothersill CE, Seymour CB, McNeill FE. Is the false-positive rate in mammography in North America too high? Br J Radiol 2016; 89: 20160045. doi: 10.1259/bjr.20160045

    Le M, McNeill FE, Seymour C, Rainbow AJ, Mothersill CE. An observed effect of ultraviolet radiation emitted from beta-irradiated HaCaT cells upon non-beta-irradiated bystander cells. Radiat Res 2015; 183(3): 279-90. doi: 10.1667/RR13827.1

    Le M, Mothersill CE, Seymour CB, Ahmad SB, Armstrong A, Rainbow AJ, McNeill FE. Factors affecting ultraviolet-A photon emission from beta-irradiated human keratinocyte cells. Physics Med Biol; 60(2015) 6371-6389.

    Conference Presentations:

    Poster presentation: Exosome release follows exposure of cells to radiation-induced biophotons to produce a bystander response. 62nd Annual Radiation Research Society Meeting, Big Island HI (2016).

    Poster presentation: Investigating the contribution of L-Tryptophan to the UV fluorescence observed from beta-irradiated cells. 15th Annual International Dose-Response Conference. University of Massachussetts Amherst, Amherst MA (2016).

    Poster presentation: Radiation-stimulated ultraviolet signal generation and response by various cell lines. 14th Annual International Dose-Response Conference. University of Massachussetts Amherst, Amherst MA (2015).

    Oral presentation: Ultraviolet-A photoemission from beta-irradiated HaCaT cells; a possible mechanism for DNA damage induction in bystander cells? 13th International Workshop on Damage to DNA. Massachusetts Institute of Technology, Cambridge MA (2014).

    Poster presentation: Ultraviolet-A photoemission from cells upon beta-irradiation and consequent bystander effects. 13th Annual International Dose-Response Conference. University of Massachussetts Amherst, Amherst MA (2014).

    Poster presentation:Secondary emission of ultraviolet radiation from human keratinocyte cells subsequent to beta irradiation as a radiation-induced bystander stress mechanism. 59th Annual Radiation Research Society Meeting, New Orleans LA (2013).

    Poster presentation: Emission of ultraviolet radiation from human keratinocytes is a potential bystander stress mechanism. 12th Annual International Dose-Response Conference. University of Massachussetts Amherst, Amherst MA (2013).

  • Biology 1A03: Cellular and Molecular Biology

    Biology 2B03: Cell Biology

    Med Rad Sci 3Y03: Biomedical Ethics from Medical Radiation Sciences

    Med Rad Sci 3X03: Research Methods in Medical Radiation Sciences

    MedPhys 4U03: Radiation Biology

McMaster University - Faculty of Science

Mailing Address

McMaster University
General Sciences Building, Room 109
1280 Main Street West
Hamilton, Ontario, Canada
L8S 4K1

Contact Information

Office Hours:
9:00 a.m. - 4:00 p.m.
Telephone Inquiries:
+1 (905) 525-9140 ext.27650
Email Inquiries:
radgrad@mcmaster.ca

McMaster University - Faculty of Science

Mailing Address

McMaster University
General Sciences Building, Room 109
1280 Main Street West
Hamilton, Ontario, Canada
L8S 4K1

Contact Information

Office Hours:
9:00 a.m. - 4:00 p.m.
Telephone Inquiries:
(905) 525-9140 ext. 27650
Email Inquiries:
radgrad@mcmaster.ca