Molecular Exercise Physiology & Muscle Aging Lab

Molecular Exercise Physiology and Muscle Aging lab

The focus of the research in the Molecular Exercise Physiology and Muscle Aging lab is on the examination of the role of exercise as an activator of satellite cells in younger and older adults.
We are interested in examining the role of cytokines such as IL-6, IGF-1 and HGF as paracrine activators of satellite cells in response to exercise and are working to reveal novel signaling mechanisms. One major achievement of our lab was the establishment of the use of flow cytometry to evaluate muscle satellite cell kinetics and provided more quantitative assessment for the understanding of their biology. We use this cutting edge methodology to show that aging impacts satellite cell activation primarily by delaying but not attenuating the response. Recently we have published work showing that exercise activated hematopoetic stems cells can alter the mesenchymal stem cell fate and that bone marrow can be pre-conditioned by exercise to better resist other stressors such as radiation.

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Department of Kinesiology | McMaster University has 1 registered member
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Professor; Associate Dean (Research & External Relations), Faculty of Science
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Research Interests:
Skeletal muscle; Aging; Exercise; Muscle stem cells; Bone marrow stem cells; Satellite cells; Nutrition
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McMaster University - Faculty of Science | Kinesiology